Professional satisfaction is a powerful driver of quality of care, the patient experience and wise resource use, and as a result is of critical importance to health system leaders and practicing physicians alike. Improvements in clinical workflow, teamwork and leadership communication are among the most potent anecdotes to the burnout which is widespread in healthcare. This session will describe practice transformation approaches that can help physicians and staff re-engineer their practices to better meet their mission, foster sound medical decision making, minimize error, increase provider quality time with patients and yet go home earlier, and create an atmosphere that patients, staff and physicians can enjoy.